Cannabinoid Receptor
Cannabinoid receptors, located throughout the body, are part of the Endocannabinoid system which is involved in a variety of physiological processes including appetite, pain-sensation, mood, and memory.
Cannabinoid receptors are of a class of cell membrane receptors under the G protein-coupled receptor superfamily. As is typical of G protein-coupled receptors, the cannabinoid receptors contain seven transmembrane spanning domains. Cannabinoid receptors are activated by three major groups of ligands: endocannabinoids, produced by the mammillary body; plant cannabinoids; and synthetic cannabinoids. There are currently two known subtypes of cannabinoid receptors, termed CB1 and CB2.
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WIN 55，212-2 mesylate是高活性的cannabinoid 受体激动剂。
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WIN 55，212-3 mesylate是CB2 拮抗剂/CB1 部分反向激动剂，WIN 55，212-2的对映体。
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TC-C 14G是活性高亲和性 CB1受体反向激动剂。
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SR 141716A是选择性 CB1 受体拮抗剂。
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SR 144528是高亲和性，选择性 CB2 反向激动剂。
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